HUMAN SPACE FLIGHTS: FACTS AND DREAMS

Authors

  • Mariano Bizzarri University La Sapienza Roma Scientific Committee of the Italian Space Agency Departmen of Experimental Medicine
  • Enrico Saggese Italian Space Agency Roma

Abstract

Manned space flight has been the great human and technological adventure of the past half-century. By putting people into places and situations unprecedented in history, it has stirred the imagination while expanding and redefining the human experience. However, space exploration obliges men to confront a hostile environment of cosmic radiation, microgravity, isolation and changes in the magnetic field. Any space traveler is therefore submitted to relevant health threats. In the twenty-first century, human space flight will continue, but it will change in the ways that science and technology have changed on Earth: it will become more networked, more global, and more oriented toward primary objectives. A new international human space flight policy can help achieve these objectives by clarifying the rationales, the ethics of acceptable risk, the role of remote presence, and the need for balance between funding and ambition to justify the risk of human lives.

References

Ariosto, L. (1516). Orlando Furioso (translated by D. Slavitt, Harvard 2009).

Augustine report, 2010. (http://www.nasa.gov/pdf/396093main_HSF_Cmte_FinalReport.pdf)

Averbeck, D. (2010). Non-targeted effects as a paradigm breaking evidence. Mutation Research, 687, 7–12.

Azzam, E. I., de Toledo, S. M., & Little, J. B. (2001). Direct evidence for the participation of gap junction mediated intercellular communication in the transmission of damage signals from a-particle irradiated to non irradiated cells. Proc. Natl Acad. Sci. USA, 98, 473–478.

Baldwin, K. M. (1996). Effect of spaceflight on the functional, biochemical, and metabolic properties of skeletal muscle. Med. Sci. Sports Exerc. 28, 983–987.

Battiston, R. (2008). The antimatter spectrometer (AMS-02): A particle physics detector in space. Nucl. Instrum. Meth. A588, 227–234.

Billica, R. D., Simmons, S. C., Mathes, K. L. et al. (2000). Perception of the medical risk of spaceflight. Aviat. Space Environ. Med., 67(5), 467–473.

Bizzarri, M. (2008). Consequences of space exploration for mankind. G Ital Nefrol. 25(6), 686–689.

Bonin, G. R. (2005). Initiating Piloted Mars Expeditions with Medium-Lift Launch Systems JBIS, 58, 302–309.

Clement, G. (2003). Musculo-skeletal system in space. In Fundamentals of space medicine. Dordrecht, Netherlands: Kluwer Academic Publishers (pp. 173–204).

Cucinotta, F. A., & Durante, M. (2006). Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol., 7(5), 431–435.

Czarnik, T. R., & Vernikos, J. (1999). Physiological changes in spaceflight that may affect drug action. J. Gravit. Physiol., 6(1), 161–164.

Durante M., & Cucinotta F. A. (2008). Heavy ion carcinogenesis and human space exploration. Nature Rev Cancer, 8, 465–472.

Durante, M., Reitz G., & Angerer, O. (2010). Space radiation research in Europe: flight experiments and ground-based studies. Radiat Environ Biophys., 49(3), 295–302.

Ephimia, M. M. (2001). Psychological and Human Factors in Long Duration Spaceflight. MJM, 6, 74–80.

ESA-Mars500 : study overview (http://www.esa.int/esaMI/Mars500/SEM7W9XX3RF_0.html)

Fritsch-Yelle, J. M., Leuenberger, U.A., D'Aunno, D.S., Rossum, A. C., Brown, T. E., Wood, M. L., Josephson, M. E., & Goldberger, A.L. (1998). An episode of ventricular tachycardia during long-duration spaceflight. Am. J. Cardiol., 81, 1391–1392.

Grigoriev, A. I., Kotovskaya, A. R., & Fomina, G. A. (2011). The human cardiovascular system during space flight. Acta Astronautica, 68, 1495–1500.

Gündel, A., Polyakov, V. V., & Zulley, J. (1997). The alteration of human sleep and circadian rhythms during spaceflight. J. Sleep Res., 6, 1–8.

Hammond, T. G., Benes, E., O’Reilly, K. C. et al. (2000). Mechanical culture conditions affect gene expression: gravity-induced changes on the space shuttle Physiol Genomics, 3, 163–173.

Heer, M., & Paloski, W. H. (2006). Space motion sickness: incidence, etiology, and countermeasures. Auton Neurosci, 129, 77–79.

Johnston, R. S. (1977). Skylab medical program overview. http://lsda.jsc.nasa.gov/books/skylab/ch01.htm.

Kondepudi, D. K., & Prigogine, I. (1981). Sensitivity of non-equilibrium systems. Physica, 107, 1–24.

Kotovskaya, A. R. (2011). The problem of artificial gravity in piloted space exploration missions. Acta Astronautica, 68, 1608–1613.

Lang, T. F., LeBlanc, A. D., Evans, H. J. et al. (2006). Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res, 21, 1224–3120.

van Loon, J. J. W. A. (2007). The Gravity Environment in Space Experiments. In: E. Brinckmann (Ed.), Biology in Space and Life on Earth. Effects of Space flight on Biological Systems (pp). WILEY-VCH Verlag.

Nicogossian, A. E. N., Pool, S. L., & Uri, J. J. (1994). Historical perspectives. In A. E. Nicogossian, C. L. Huntoon, S. L. Pool (Eds.), Space Physiology and Medicine (pp. 3–49). Philadelphia: Lea & Febiger. 3rd ed.

Parker, E. N. (2006). Shielding space travellers, Sci. Amer., 294, 40–47.

Petrov, V. M. (2011). Using radiation risk for assessment of space radiation hazard. Acta Astronautica, 68, 1424–1429.

Putcha L., & Cintron N. M. (1991). Pharmacokinetic consequences of spaceflight. Ann. NY Acad. Sci., 618, 615–618

Rapp, D. (2007). Human Mission to Mars. Springer Praxis, 17–18.

Reyes, C., Freeman-Perez, S., & Fritsch-Yelle, (1999). J. Orthostatic intolerance following short and long duration spaceflight. FASEB J. 13, A1048.

Rittweger, J., Simunic, B., Bilancio, G. et al. (2009). Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment. Bone, 44, 612–618.

Sandonà, D., Desaphy, J. F., Camerino, G. M. et al. (2012). Adaptation of Mouse Skeletal Muscle to Long-Term Microgravity in the MDS Mission. PLoS One, 7(3), e33232

Salotti, J. M. (2011). Simplified scenario for manned Mars mission. Acta Astronautica, 69, 266–279.

Senot, P., Zago, M., Le Séach, A., Zaoui, M., Berthoz, A., Lacquaniti, F., & McIntyre, J. (2012). When up is down in 0g: how gravity sensing affects the timing of interceptive actions. J. Neurosci, 32(6), 1969–1973.

Shackelford, L. C. (2008). Musculoskeletal response to space flight. In M. R. Barratt, S. L. Pool SL (Eds.) Principles of clinical medicine for space flight (pp 293–306). New York (NY): Springer Science and Business Media.

Sherwood, B. (2011). Comparing future options for human space flight. Acta astronautica, 69, 346–353.

Sihver, L. (2008). Physics and biophysics experiments needed for improved risk assessment in space. Acta Astronautica, 63, 886–898.

Smith, S. M. Wastney, M. E., Morukov, B. V., Larina, I. M., Nyquist. L. E. et al. (1999). Calcium metabolism before, during and after a 3-month spaceflight: kinetic and biochemical changes. Am. J. Physiol., 277, R1–R10.

Stein, T. P., Schluter, M. D., & Moldawer, L. L. (1999). Endocrine relationships during human spaceflight. Endocrinol Metab, 39, E155–E162.

Taylor, G. R. (1993). Overview of spaceflight immunology studies. J. Leukoc. Biol., 54, 179–188.

Townsend, L. O. (2001). Overview of active methods for shielding spacecraft from energetic space radiation. Phys. Med., 17 (Suppl. 1), 84–85.

Turner, J. (1997). Telemedicine from NASA’s beginnings. Aerospace Technol. Innov., 5(3), 4–5.

Whedon, G. D., & Rambaut P. C. (2006). Effects of long-duration space flight on calcium metabolism: Review of human studies from Skylab to the present. Acta Astronautica, 58, 59–81

White, R. J., & Averner, M. (2001). Humans in Space. Nature, 409, 1115–1118.

Whitson, P. A., Pietrzyk , R. A., & Sams, C. F. (1999). Space flight and the risk of renal stones. J. Gravit. Physiol., 6(1), 87–88.

Williams, D., Kuipers, A., Mukai, C., & Thirsk, R. (2009). Acclimation during space flight: effects on human physiology. CMAJ, 180, 1317–1323.

Williams, D. R. (2003). The Biomedical challenges of Space Flight. Ann Rev Med, 54, 245–256.

Zago, M., & Lacquaniti, F. (2005). Internal model of gravity for hand interception: parametric adaptation to zero-gravity visual targets on Earth. J Neurophysiol. 94(2), 1346–1357.

Downloads

Published

24-12-2011

How to Cite

Bizzarri, M., & Saggese, E. (2011). HUMAN SPACE FLIGHTS: FACTS AND DREAMS. Annales Kinesiologiae, 2(2). Retrieved from https://ojs.zrs-kp.si/index.php/AK/article/view/74

Issue

Section

Articles