HEART RATE REPRODUCIBILITY ASSESSED BY SURROGATE DATA ANALYSIS

Authors

  • Nandu Goswami Medical University Graz, Center of Physiological Medicine, Institute of Physiology
  • Andreas Rössler Medical University Graz, Center of Physiological Medicine, Institute of Physiology
  • Helmut Karl Lackner Medical University Graz, Center of Physiological Medicine, Institute of Physiology
  • Jerry Batzel Karl Franzens University Graz, Institute of Mathematics and Scientific Computing
  • Helmut Hinghofer-Szalkay Medical University Graz, Center of Physiological Medicine, Institute of Physiology

Abstract

Purpose: Combinations of head up tilt (HUT) and lower body negative pressure (LBNP) have been used to study syncope. Since HUT invokes initial, partly transient cardiovascular responses, in this work we employed the HUT phase (5 min in all subjects) to arrive at a state of orthostatic loading to be used as a reference load for subsequent added LBNP phases. We investigated the pattern of cardiovascular responses during the LBNP phase across four runs for test subjects using surrogate data analysis. Methods: Ten healthy young males were subjected to HUT + LBNP to achieve a pre-syncopal end-point in four tests each separated by ≥2 weeks. Beat to beat continuous hemodynamic variables were measured and analyzed. Results: Expected heart rate and stroke volume responses changes during the LBNP phase were observed. Heart rate was the only variable that showed reproducibility between subjects across four runs. Conclusion: During LBNP phase of the combined HUT+ LBNP protocol, heart rate was the only reproducible variable, thus confirming its central role during added LBNP in upright tilted men. Surrogate data analysis is useful tool to differentiate physiological responses from chance events in repeated runs.

References

Al-Shamma, Y. M. & Hainsworth, R. (1987). A quantitative comparison of the circulatory responses in humans to graded upright tilting and lower body negative pressure. In: Cardiogenic Reflexes, edited by Hainsworth R, McWilliam PN, & Mary DASG. Oxford, UK; University Press.

Blaber, A. P., Yamamoto, Y., & Hughson, R. L. (1995). Methodology of sponataneous baroreflex relationship assessed by surrogate data analysis. American Journal of Physiology-Heart and Circulatory Physiololg 268: H1682-H168.

Convertino, V. A. & Sather, T. M. (2000). Effects of cholinergic and beta-adrenergic blockade on orthostatic tolerance in healthy subjects. Clinical Autonomic Research 10: 327-336.

El-Bedawi, K. M., & Hainsworth, R. (1994). Combined head-up tilt and lower body suction: a test of orthostatic tolerance. Clinical Autonomic Research 4: 41-44.

Evans, J. M., Leonelli, F. M., Ziegler, M. G., McIntosh, C. M., Patwardhan, A. R., Ertl, A. C., Kim, C. S., & Knapp, C. F. (2001). Epinephrine, vasodilation and hemoconcentration in syncopal, healthy men and women. Autonomic Neuroscience 93: 79-90.

Evans, J. M., Stenger, M. B., Moore, F. B., Hinghofer-Szalkay, H., Rossler, A., Patwardhan, A. R., Brown, D. R., Ziegler, M. G., & Knapp, C. F. (2004). Centrifuge training increases presyncopal orthostatic tolerance in ambulatory men. Aviation Space and Environmental Medicine 75: 850-858.

Gao, Y. F., Goswami, N., Grasser, E., Rossler, A., Stoger, E., Schwaberger, G., & Hinghofer-Szalkay, H. G. (2008). Radix Astragali and orthostatic response: A double-masked crossover study. Aviation Space and Environmental Medicine 79: 94-98.

Goswami, N., Grasser, E., Roessler, A., Schneditz, D., & Hinghofer-Szalkay, H. (2009a). The cardiovascular response to lower body negative pressure in humans depends on seal location. Physiological Research 58: 311-318.

Goswami, N., Lackner, H. K., Grasser, E. K., & Hinghofer-Szalkay, H. (2009b). Individual stability of orthostatic tolerance response. Acta Physiologica Hungarica 96: 157-166.

Goswami, N., Rössler, A., Lackner, H. K., Schneditz, D., Grasser, E., & Hinghofer-Szalkay, H. (2009c). Heart rate and stroke volume response patterns to augmented orthostatic stress. Clinical Autonomic Research 19: 157-165.

Goswami, N., Loeppky, J. A., & Hinghofer-Szalkay H. (2008). LBNP: Past protocols and technical considerations for experimental design. Aviation Space and Environmental Medicine 79: 459-471.

Grasser, E., Goswami, N., & Hinghofer-Szalkay, G. (2008a). Presyncopal cardiac contractility and autonomic activity in young healthy males. Physiological Research 58: 817-26.

Grasser, E., Goswami, N., Roessler, A., Vrecko, K., & Hinghofer-Szalkay H. (2008b). Hemodynamic and neurohormonal responses to extreme orthostatic stress in physically fit young adults. Acta Astronautica 64: 688-696.

Hainsworth, R., & El-Bedawi, K. M. (1994). Orthostatic tolerance in patients with unexplained syncope. Clinical Autonomic Research 4: 239-244.

Howden, R., Tranfield, P. A., Lightfoot, J. T., Brown, S. J., & Swaine, I. L. (2001). The reproducibility of tolerance to lower-body negative pressure and its quantification. European Journal of Applied Physiology 84: 462-468.

Julius, S. (1988). The blood-pressure seeking properties of the central nervous-system. Journal of Hypertension 6: 177-185.

Lelorier, P., Klein, G. J., Krahn, A., Yee, R., Skanes, A., & Shoemaker, J. K. (2003). Combined head-up tilt and lower body negative pressure as an experimental model of orthostatic syncope. Journal of Cardiovascular Electrophysiology 14: 920-924.

Lightfoot, J. T., Hilton, F.. & Fortney, S. M. (1991). Repeatability and protocol comparability of presyncopal symptom limited lower body negative pressure exposures. Aviation Space and Environmental Medicine 62: 19-25.

Mosqueda-Garcia, R., Furlan, R., Tank, J., & Fernandez-Violante, R. (2001). The elusive pathophysiology of neurally mediated syncope. Circulation 102: 2898-2906.

Theiler, J., Eubank, S., Longtin, A., Galdrikian, B., & Farmer, J. D. (1992). Testing for non-linearity in time series: the method of surrogate data. Physica. 58: 77-94.

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How to Cite

Goswami, N., Rössler, A., Lackner, H. K., Batzel, J., & Hinghofer-Szalkay, H. (2015). HEART RATE REPRODUCIBILITY ASSESSED BY SURROGATE DATA ANALYSIS. Annales Kinesiologiae, 3(1). Retrieved from https://ojs.zrs-kp.si/index.php/AK/article/view/61

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Vol. 3 No. 1 (2012)

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