METABOLIC ADAPTATION TO INACTIVE LIFESTYLE: FROM MUSCLE ATROPHY TO CARDIOVASCULAR RISK

Authors

  • Francesco Agostini University of Trieste, Department of Medical, Technological and Translational Sciences, Division of Internal Medicine
  • Sara Mazzucco University of Trieste, Department of Medical, Technological and Translational Sciences, Division of Internal Medicine
  • Gianni Biolo University of Trieste, Department of Medical, Technological and Translational Sciences, Division of Internal Medicine

Abstract

Inactivity is known to principally induce muscle atrophy, determined by unbalanced protein synthesis and degradation and to enhance general cardiovascular risk. In parallel, unloading can upregulate whole body oxidative stress and the action of antioxidant factors, as physiological response. This alteration is accompanied by enhanced systemic inflammation. Growing evidence in animal models suggest that inflammation and oxidative stress can play a causative role in inactivity mediated muscle atrophy. The present review is focused on human studies linking inactivity mediated oxidative stress and inflammation to unloading related atrophy. Recent works evidencing enhanced cardiovascular risk after unloading are reported. In addition, evidence regarding the role of inflammation in cardiovascular drawbacks linked to inactivity are discussed.

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Annales Kinesiologiae 2010

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Agostini, F., Mazzucco, S., & Biolo, G. (2015). METABOLIC ADAPTATION TO INACTIVE LIFESTYLE: FROM MUSCLE ATROPHY TO CARDIOVASCULAR RISK. Annales Kinesiologiae, 1(1). Retrieved from http://ojs.zrs-kp.si/index.php/AK/article/view/42

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