Fat mass to fat- free mass ratio and body composition in participants with chronic leg problems
DOI:
https://doi.org/10.35469/ak.2022.344Keywords:
Fat-mass, fat-free mass, waist circumference, older adults, knee, hipAbstract
Background & aim: Low fat-free mass (FFM) or high fat mass (FM) in older adults are abnormal body composition phenotypes associated with morbidity. The dual burden of excessive FM and low FFM may lead to a higher risk of cardiovascular and other diseases and disability and lower physical performance compared with individuals with normal body composition or low FFM or high FM alone. Both conditions lead to poorer health and can be identified by a high FM/FFM ratio. Because few studies have examined the effects of abnormal body composition using the FM/FFM ratio, the aim of this study is to determine the FM/FFM values by gender in patients with knee and hip pathologies and compare them with body composition parameters. This condition is important when surgery is required because abnormal body composition leads to an increase in infections and other postoperative complications.
Methods: A total of 93 participants aged 64.71 ± 7.71 years in women and 65.9 ± 9.9 years in men with a body mass index (BMI) ≥25 kg/m2 were recruited from the Valdoltra Orthopaedic Hospital (Ankaran, Slovenia). The waist circumference (WC) and anthropometric data (BMI), as well as body composition data (FM, FFM, % of body water, estimated by bioelectrical impedance - BIA) were measured. In addition, the body composition phenotypes (FM/FFM ratio) were calculated.
Results: The FM/FFM index was higher in females. The female group with FM/FFM (0.68) and those with a higher FM/FFM (0.92) correlated positively with WC. Male participants were excluded for further analysis because only two males had FM/FFM > 0.80. The FM/FFM of the remaining male participants was 0.53 ± 0.09.
Conclusions: FM/FFM provide information on patient body composition and identify individuals at risk of body composition abnormalities in women only.
References
Batsis, J. A., Mackenzie, T. A., Bartels, S. J., Sahakyan, K. R., Somers, V. K., & Lopez-Jimenez, F. (2016). Diagnostic accuracy of body mass index to identify obesity in older adults: NHANES 1999–2004. International Journal of Obesity, 40(5), 761–767. https://doi.org/10.1038/ijo.2015.243
Biolo, G., Di Girolamo, F. G., Breglia, A., Chiuc, M., Baglio, V., Vinci, P., … Situlin, R. (2015). Inverse relationship between “a body shape index” (ABSI) and fat-free mass in women and men: Insights into mechanisms of sarcopenic obesity. Clinical Nutrition (Edinburgh, Scotland), 34(2), 323–327. https://doi.org/10.1016/j.clnu.2014.03.015
Delmonico, M. J., & Beck, D. T. (2017). The Current Understanding of Sarcopenia: Emerging Tools and Interventional Possibilities. American Journal of Lifestyle Medicine, 11(2), 167–181. https://doi.org/10.1177/1559827615594343
Dhawan, D., & Sharma, S. (2020). Abdominal Obesity, Adipokines and Non-communicable Diseases. The Journal of Steroid Biochemistry and Molecular Biology, 203, 105737. https://doi.org/10.1016/j.jsbmb.2020.105737
Godziuk, K., Woodhouse, L. J., Prado, C. M., & Forhan, M. (2020). Clinical screening and identification of sarcopenic obesity in adults with advanced knee osteoarthritis. Clinical Nutrition ESPEN, 40, 340–348. https://doi.org/10.1016/j.clnesp.2020.08.005
Kim, J. Y., Nolte, L. A., Hansen, P. A., Han, D. H., Ferguson, K., Thompson, P. A., & Holloszy, J. O. (2000). High-fat diet-induced muscle insulin resistance: Relationship to visceral fat mass. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 279(6), R2057-2065. https://doi.org/10.1152/ajpregu.2000.279.6.R2057
Ma, S., Xi, B., Yang, L., Sun, J., Zhao, M., & Bovet, P. (2021). Trends in the prevalence of overweight, obesity, and abdominal obesity among Chinese adults between 1993 and 2015. International Journal of Obesity, 45(2), 427–437. https://doi.org/10.1038/s41366-020-00698-x
Merchant, R. A., Seetharaman, S., Au, L., Wong, M. W. K., Wong, B. L. L., Tan, L. F., … Morley, J. E. (2021). Relationship of Fat Mass Index and Fat Free Mass Index With Body Mass Index and Association With Function, Cognition and Sarcopenia in Pre-Frail Older Adults. Frontiers in Endocrinology, 12, 765415. https://doi.org/10.3389/fendo.2021.765415
Morse, W. I., & Soeldner, J. S. (1964). The non-adipose body mass of obese women: Evidence of increased muscularity. Canadian Medical Association Journal, 90, 723–725.
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., … Isenovic, E. R. (2021). Leptin and Obesity: Role and Clinical Implication. Frontiers in Endocrinology, 12, 585887. https://doi.org/10.3389/fendo.2021.585887
Prado, C. M. M., Wells, J. C. K., Smith, S. R., Stephan, B. C. M., & Siervo, M. (2012). Sarcopenic obesity: A Critical appraisal of the current evidence. Clinical Nutrition (Edinburgh, Scotland), 31(5), 583–601. https://doi.org/10.1016/j.clnu.2012.06.010
Roubenoff, R. (2000). Sarcopenia and its implications for the elderly. European Journal of Clinical Nutrition, 54(3), S40–S47. https://doi.org/10.1038/sj.ejcn.1601024
Rugila, D. F., Oliveira, J. M., Machado, F. V. C., Correia, N. S., Puzzi, V. C., Passos, N. F. P., … Furlanetto, K. C. (2022). Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma. Heart & Lung: The Journal of Critical Care, 56, 154–160. https://doi.org/10.1016/j.hrtlng.2022.07.006
Walsh, T. P., Arnold, J. B., Evans, A. M., Yaxley, A., Damarell, R. A., & Shanahan, E. M. (2018). The association between body fat and musculoskeletal pain: A systematic review and meta-analysis. BMC Musculoskeletal Disorders, 19(1), 233. https://doi.org/10.1186/s12891-018-2137-0
Younger, J., Kapphahn, K., Brennan, K., Sullivan, S. D., & Stefanick, M. L. (2016). Association of Leptin with Body Pain in Women. Journal of Women’s Health, 25(7), 752–760. https://doi.org/10.1089/jwh.2015.5509
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